Experts Identify Inhibitor Causing Male Pattern Baldness and Target for Hair Loss Treatments

Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified an abnormal amount a protein called Prostaglandin D2 in the bald scalp of men with male pattern baldness, a discovery that may lead directly to new treatments for the most common cause of hair loss in men. In both human and animal models, researchers found that a prostaglandin known as PGD2 and its derivative, 15-dPGJ2, inhibit hair growth. The PGD2-related inhibition occurred through a receptor called GPR44, which is a promising therapeutic target for androgenetic alopecia in both men and women with hair loss and thinning. The study is published in Science Translational Medicine.

Male pattern baldness strikes 8 of 10 men under 70 years old, and causes hair follicles to shrink and produce microscopic hairs, which grow for a shorter duration of time than normal follicles.

Researchers took an unbiased approach when scanning for potential biological causes of baldness, looking in scalp tissue from balding and non-bald spots from men with male pattern baldness and then corroborating findings in mouse models. They found that levels of PGD2 were elevated in bald scalp tissue at levels 3 times greater than what was found in comparative haired scalp of men with androgenetic alopecia. When PGD2 was added to cultured hair follicles, PGD2-treated hair was significantly shortened, while PGD2's derivative, 15-dPGJ2, completely inhibited hair growth.

"Although a different prostaglandin was known to increase hair growth, our findings were unexpected, as prostaglandins haven't been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells," said George Cotsarelis, MD, chair and professor of Dermatology, and senior author on the studies. In a Penn study published in the Journal of Clinical Investigation last year, underlying hair follicle stem cells were found intact, suggesting that the scalp was lacking an activator or something was inhibiting hair follicle growth.

Prostaglandins are well characterized for their role in many bodily functions — controlling cell growth, constricting and dilating smooth muscle tissue — and a different prostaglandin (F2alpha) is known to increase hair growth. Researchers found that as PGD2 inhibits hair growth, other prostaglandins work in opposition, enhancing and regulating the speed of hair growth.

While these studies looked at AGA in men, the researchers noted that prostaglandins may represent a common pathway shared by both men and women with AGA. Future studies, potentially testing topical treatments that may target GPR44, can determine whether targeting prostaglandins will benefit woman with AGA as well.

The research team consisted of Dr. Cotsarelis, lead author Luis Garza, MD, PhD, (former post-doctoral fellow at Penn, now at Johns Hopkins University School of Medicine) and Yaping Liu (now at Merck & company), Zaixin Yang, Brinda Alagesan, Scott Norberg, Tailun Zhao, Hanz Blatt, from Penn's Dermatology department; Garrett FitzGerald and John Lawson from Penn's Department of Pharmacology and the Institute for Translational Medicine and Therapeutics; David Stanton and Lee Carrasco from Penn's Department of Oral and Maxillofacial Surgery and colleagues at Gillette, and University of Texas M.D. Anderson Cancer Center.

The study was funded by grants from the National Institutes of Health (R01-AR46837, P30-AR057217, 5R01AR055309 and K08AR055666, 5-P30-AR-057217-02), the Pennsylvania Department of Health, the Edwin and Fannie Gray Hall Center for Human Appearance at Penn Medicine, American Skin Association, Dermatology Foundation and L'Oreal. Drs. Cotsarelis and Garza are co-inventors on a patent owned by the University of Pennsylvania describing the PGD2 pathway as a target for inhibiting hair loss.

Hair loss triggers toupee, goatee debate

On Thurs. March 22 I woke up to find five hairs had fallen from my head and rested atop my pillow. This is five times more than the usual — one. While some of you wouldn’t consider this cause for concern and would probably ignore it, I took a different approach and prepared for my imminent baldness.

As a below-average looking guy, there isn’t much room between the way I look now and a completely unacceptable physical appearance. If I lose my hair I could be dangerously close to crossing the line into, “walk around the block to avoid me” ugly. Granted, my hair is probably only my eighth-best feature, but without it, I expose my third-worst feature, my sixth-worst feature and my ninth-worst feature: my oddly shaped head, inability to grow a cool goatee and the Texas-shaped birthmark behind my ear, respectively.

I wasn’t planning on growing a goatee until well into my 30s. But as we all know, bald guys have goatees. Or have at least tried the goatee look. Taking the leap to grow a goatee is scary, especially for me, since my facial hair is weird looking. Go ahead and mess around with a mustache, but you absolutely do not want to grow a goatee until you’re positively ready. I’m not ready. But without hair on my head I would have to abide by the unwritten rule to attempt it.

I know myself. I’ll be one of those bald guys who can’t let it go. I’ll try the comb over look, and maybe even the bald guy pulled back ponytail look. My only hope is that my friends or family will be kind enough to tell me how ridiculous I look before it’s too late.

Some guys can pull off hair loss: Bruce Willis, Michael Jordan, Professor Cecil. They don’t know how lucky they are; it doesn’t end well for the rest of us. If I knew losing my hair would make me look like John McClane, I’d be like, “Heck yeah, bring on the bald!” But no, I will look like E.T. So I’ve decided that when my baldness occurs, I will be a toupee wearer and there is nothing wrong with that. Okay!?

Baldness doesn’t really run in my family, but neither does awesomeness, and I’ve pretty much been rocking that since birth. Anything is possible. I have already ordered three toupees online from a sketchy toupee-selling website that probably identity-thefted me already. Once, and if, they arrive in the mail I will post pictures and tally your votes for the best one. Hopefully by the time I need to wear it, you’ll have forgotten all about this and I can go on with my hair having life. Only time will tell.

Is Revivogen Effective in Treating Hair Loss?

There are some areas of knowledge where you have to separate fact from fiction on the net. Most do not take the time to look further in the search results, and they often lose out on what they need. It is usually a frequent effect of the way search engine algorithms are written – so you are not alone. The following information concerning how to prevent razor burn is a consequence of all those let-downs people have. So just finish reading this to glean more than enough to begin forming a great foundation.

The Revivogen line of hair care products is formulated to deal with hair loss. It was created by leading skin experts, and created to work at the hair follicle. DHT is a hormone that has been found to be one of the leading causes of hair loss. The body produces DHT inside the hair follicle. Revivogen has special ingredients which were found to stop DHT production, and in turn slow down hair loss.

The Revivogen line is made up of 3 products: the Bio-Cleansing Shampoo, Hair Thickening Conditioner, and Scalp Therapy serum. They’re intended to be used collectively. There are tiny amounts of growth activating compounds, and also other ingredients to promote optimal hair health, in the shampoo and conditioner. The Scalp Therapy serum is where the hair loss treatment kicks off. It contains highly concentrated quantities of DHT blocking, growth promoting ingredients.

If your hair loss has only just begun, these 3 products that constitute the Revivogen line may just be the best solution for you. If your hair loss is acute or in the advanced stages, you would probably do better with something stronger, such as Rogain, although Revivogen might work as a supporting treatment.

Revivogen has received a lot of rave reviews, but there are folks who say it did not work for them. One of the most common complaints of dissatisfied users is that hair loss increased after only one or two uses. But, this is actually to be expected and it’s even pointed out on the manufacturer’s website. The Revivogen products sparks hair follicle growth, so existing hair starts to grow much faster. Hair strands do not immediately go from healthy to gone. With the treatment, the dying hair strands are still connected to the scalp during the transition period. You have just read a fairly thorough overview on best hair removal cream, but that is nothing extensive by any means. As usual, you can increase your efforts when your knowledge is more comprehensive and deeper. In a moment, we will talk about this much deeper kind of knowledge that we feel greatly develops upon the above. We know you will gain deeper ideas into your own needs and be able to see some added benefits.

Finding the Best Hair Loss Treatments

Finding the Best Hair Loss Treatments

For both women and men, dropping hair can typically be really distressing. Typically, it’utes because of hereditary factors as opposed to any medical condition, but many folks have a solid desire to carry on their head of hair! There are a number regarding methods you can get any time facing hair loss, and also we’lmost all be checking out a few of these in this article.

Those people which have carried out some study most likely realize that laser treatment regarding hair thinning has become ever more popular. Lasers, which can be tuned with a particular rate of recurrence, can in fact stimulate elevated blood circulation in the head which will consequently aid your fur start to develop. Many individuals possess began using what are known as laser beam hair combs, a portable gadget that really provides very small laser treatment inside it which can be useful for this sort of treatment. Physicians can also perform low-level laserlight therapy, as well as could possibly function as very first individual to see regarding whether it therapy option is acceptable for you personally. You could obtain a laser beam hair comb in a shop, and give that a go, despite the fact that your results can vary. You are able to sense safe knowing that they will FDA provides in fact authorized the product to use, however has not assured that they can work. In the event you actually want to determine if laser treatment will work on your scalp, ask your medical professional and use the particular high-tech types they’ve available. Laser skin treatment at least displays real promise as a good and inexpensive approach to promote new hair growth.

A quantity of dietary supplements might be helpful thinning hair treatments. Vitamin supplements, herbs and also nutrients could be one of them.

The truth is, not all hair thinning may be stopped. This isn’capital t the end with the a whole lot worse though, there are numerous other choices you can look at. One is to select a hair item. These days you’ve got the right choices to choose from in this area, because there are some reasonable looking wigs now. The hair bit or even hairpiece produced from genuine real human hair that matches well will be really difficult to identify from your actual head of hair. Of course, a quality hair bit isn’capital t inexpensive, and you also intend to make positive you obtain the one that suits properly and appearance fantastic. If your specific hair thinning scenario can’t be remedied by normal treatments, this option can be a good option for you personally.

Hair loss can usually be treated in several methods, as you can tell out of this article. A few entail merely giving you better eating habits and seeking certain dietary supplements, while others entail costly surgical treatments. Before you decide to really choose a particular treatment you need to learn the main cause of nice hair damage. If there’s nothing supporting there will always be hairpieces, hairpieces and less difficult for you to use.

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